Protein Modeling

We develop methodologies for modeling structures and their interactions including protein-protein interactions (FRODOCK) and ab initio loop modeling (RCD). Our Knowledge-base ORientational Potential (KORP) derived from known protein structures by classical Boltzmann inversion and only depends on the pairwise relative orientation and position of three backbone atoms had been successfully used in protein and loop modeling (KORP), protein-ligand (KORP-PL) and stability prediction upon mutation (KORPM).