Hybrid methods

Hybrid methods

Bridging the resolution gap with hybrid methods
Protein modeling

Protein modeling

Modeling protein structures and their interactions
Multiscale dynamics

Multiscale dynamics

Exploring the macromolecular biomachines dynamics
Drug Discovery

Drug Discovery

Computer-aided rational drug design and discovery

The original DFprot web server for predicting main-chain deformability from a single protein conformation has been replaced by http://imods.chaconlab.org/ that includes a more robust way to performs a normal-mode analysis (in internal coordinates). In this server you can calculated from a uploaded structure its capability to deform at each of its residues. In any case, you can still download the executable to calculate the deformability based on NMA in Cartesian coordinates.   

References


Garzón JI, J. A. Kovacs, R. Abagyan, and P. Chacón. Dfprot:A webtool for predicting local chain deformability Bioinformatics. (2007) Apr 1;23(7):901-2. 11