19 June 2010
ADP_EM is ultra fast multiresolution fitting tool which has been specially designed to support high throughput coverage. The method uses spherical harmonics to effectively speed up the rotational scan. It can be considered as a practical step-down of the Fast Rotational Matching (FRM) described elsewhere in Kovacs et al. 2003. Please, download the program and test by yourself the efficiency and robustness reached with this new approach.
Jose Ignacio Garzón, Julio A. Kovacs, Ruben Abagyan, and P. Chacón. (2007) ADP_EM: Fast exhaustive multi-resolution docking for high-throughput coverage. Bioinformatics. 23(4):427-33
Julio A. Kovacs, Pablo Chacón, Yao Cong, Essam Metwally, and Willy Wriggers (2003) Fast Rotational Matching of Rigid Bodies by Fast Fourier Transform Acceleration of Five Degrees of Freedom. Acta Cryst. D. 59:1371-1376.